Faculty Profile
Address:
630 West 168th Street
Room 12-511
New York, NY 10032
Phone: 212-305-7930
Fax: 212-305-3970
| Education and Training | ||
| Ph.D. | 1975 | Cornell University |
Affiliations
Stem
Cell Consortium
Department
of Pathology
Anatomy & Cell
Biology
Center
for Neurobiology and Behavior
Collaborations
Collaborate with other investigators on projects investigating growth
factors and gene expression in the developing enteric nervous system.
Training
Activities
Training
program in Anatomy & Cell Biology
Doctoral
Program in Neurobiology & Behavior
Organize,
teach, and administer three first year courses for medical, dental and
graduate students.
- Course Director: Human Development
- Section Director: Histology, Science Basic to the Practice of Medicine
(SBPM)
- Course director: Cell Biology of Tissues and Organs
| Taube
P. Rothman, Ph.D. Professor of Clinical Pathology in Anatomy & Cell Biology and the Center for Neurobiology & Behavior |
Research
Summary
Study requirements for progressive restriction of developmental potential
and interactions between neural crest derived precursor cells and extracellular
matrix molecules and growth factors in the developing enteric nervous
system.
Research is in collaboration with other investigators on projects investigating growth factors and gene expression in the developing enteric nervous system.
Service
Activities
Course Director: Human Development
Section Director: Histology, Science Basic to the Practice of Medicine
(SBPM) Course director: Cell Biology of Tissues and Organs
Organize, administer and teach three first year courses at Columbia University for medical (College of Physicians and Surgeons), dental (School of Dental and Oral Surgery) and graduate students (Graduate School of Arts and Sciences).
Selected Publications
1. Rothman, T.P., Le Douarin, N.M., Fontaine-Pérus, J.C. and Gershon, M.D. (1993) Colonization of the host's gut by neural crest-derived cells re-migrating from segments of developing bowel back-grafted to vagal or sacral regions of younger host embryos. Dev. Dynam., 196:217-233.
2. Rothman, T.P., Goldowitz, D. and Gershon, M.D. (1993) Inhibition of migration of neural crest-derived cells by the abnormal mesenchyme of the presumptive aganglionic bowel of ls/ls mice: analysis with aggregation and interspecies chimeras. Dev. Biol., 159:559-573.
3. Rothman, T.P., Chen, J., Howard, M.J., Costantini, F., Schuchardt, A., Pachnis, V. and Gershon, M.D. (1996) Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls/ls but not c-ret-/- mice. Dev. Biol., 178:498-513.
4. Wu, J.J., Chen, J-X., Rothman, T.P., Gershon, M.D. (1999) Inhibition of in vitro enteric neuronal development by enthothelin-3: mediation by endothelin B receptors. Development 126:1161-1173.
5. Wu, J.J., Rothman, T.P. and Gershon, M.D. (2000) Development of the interstitial cell of Cajal: Origin, Kit dependence and neuronal and nonneuronal sources of Kit lignd. J. Neurosci. Res. 59:384-401.
6. Chalazonitis A, Pham TD, Rothman TP, DiStefano PS, Bothwell M, Blair-Flynn J, Tessarollo L, Gershon MD. Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons. J Neurosci. 2001 Aug 1;21(15):5620-36.
Recently
Completed Projects
The
Abnormal Terminal Colon of the ls/ls Mutant Mouse
The objective of this research was to investigate the pathogenesis of
congenital neuromuscular disorders of the gastrointestinal tract
12/1985-1/2001
Developmental
Potential of Cells from the Neural Crest
The objective of this project was to evaluate the developmental potential
of the neural crest-derived precursor cells that colonize the avian bowel.
NIH
3/1987-2/1997
Prior to
1985
Collaboration
with Nicole LeDouarin (Paris France), research grants from the Disautonomia
Foundation and the March of Dimes.
Honors
and Awards
Phi
Beta Kappa
Kane
Prize in Biology, 1969
Sigma
Xi
Phi
Sigma
Kappa
Delta Pi
Basil
O'Connor Award of the National Foundation March of Dimes
Charles
W. Bohmfalk Award for Distinguished Contributions to Teaching in the
Pre-Clinical Years 1996.
Committee/Council
Memberships
First year Faculty committees for both P&S and SDOS
Curriculum Committees for both P&S and SDOS
Keywords
neural crest, enteric nervous system, peripheral nervous system, developmental
potential